{"id":59315,"date":"2023-08-29T11:16:07","date_gmt":"2023-08-29T09:16:07","guid":{"rendered":"https:\/\/www.darmklachten.nl\/testen\/eosinophil-derived-neurotoxin-edn\/"},"modified":"2026-10-16T12:26:43","modified_gmt":"2026-10-16T10:26:43","slug":"eosinophil-derived-neurotoxin-edn","status":"publish","type":"product","link":"https:\/\/www.darmklachten.nl\/en\/testen\/eosinophil-derived-neurotoxin-edn\/","title":{"rendered":"Eosinophil-derived Neurotoxin (EDN)"},"content":{"rendered":"<div class=\"wpb-content-wrapper\" id=\"wpb-content-root\">[vc_row el_class=&#8221;dk-hero&#8221; el_id=&#8221;edn-productinformatie&#8221;][vc_column][vc_column_text]\n<div class=\"dk-hero__inner\"><span class=\"dk-eyebrow\">Stool test<\/span><\/p>\n<h2>Eosinophil-derived neurotoxin (EDN) \u2013 insight into immune activity in the gut<\/h2>\n<p class=\"dk-lead\">Do you have recurring gastrointestinal complaints and want to know whether certain immune cells in your gut are particularly active? This stool test measures eosinophil-derived neurotoxin (EDN). This protein is released when eosinophils, a type of white blood cell, are active.<\/p>\n<p class=\"dk-hero__note\">The result can help determine whether further testing may be useful. The test provides information about <strong>eosinophilic immune activity<\/strong>, but does not show its precise cause.<\/p>\n<details class=\"dk-quicknav\">\n<summary class=\"dk-quicknav__summary\"><span class=\"dk-quicknav__summary-label\"><br \/>\n<strong>Quick navigation<\/strong><br \/>\n<span class=\"dk-quicknav__state dk-quicknav__state--closed\">show<\/span><br \/>\n<span class=\"dk-quicknav__state dk-quicknav__state--open\">hide<\/span><br \/>\n<\/span><\/p>\n<\/summary>\n<div class=\"dk-quicknav__body\">\n<p class=\"dk-quicknav__intro\">Go directly to the information you are looking for.<\/p>\n<div class=\"dk-quicknav__links\"><a href=\"#wanneer-geschikt\">When is it suitable?<\/a><br \/>\n<a href=\"#wat-onderzoeken-we\">What do we test?<\/a><br \/>\n<a href=\"#wat-vertelt-de-uitslag\">What does the result tell you?<\/a><br \/>\n<a href=\"#uitleg-edn\">EDN explained<\/a><br \/>\n<a href=\"#hoe-werkt-de-test\">How does the test work?<\/a><br \/>\n<a href=\"#uitslag-en-vervolgstappen\">Results and next steps<\/a><br \/>\n<a href=\"#veelgestelde-vragen\">Frequently asked questions<\/a><br \/>\n<a href=\"#contact-over-de-test\">Contact<\/a><br \/>\n<a href=\"#test-aanvragen\">Order the test<\/a><\/div>\n<\/div>\n<\/details>\n<\/div>\n[\/vc_column_text][\/vc_column][\/vc_row]\n[vc_row el_class=&#8221;dk-section dk-anchor-section&#8221; el_id=&#8221;wanneer-geschikt&#8221;][vc_column]\n[vc_column_text]\n<div class=\"dk-category-heading\">\n<div class=\"dk-category-heading__accent\" aria-hidden=\"true\"><\/div>\n<div>\n<h2>When is this test suitable?<\/h2>\n<p>Targeted additional testing when you want to know more about eosinophilic immune activity in the gut.<\/p>\n<\/div>\n<\/div>\n<div class=\"dk-card\">\n<ul>\n<li>You have recurring abdominal pain, diarrhoea or other gastrointestinal complaints without a clear cause.<\/li>\n<li>Your symptoms seem to be related to food and you want to know more about immune activity in the gut.<\/li>\n<li>In addition to gastrointestinal complaints, you have a history of allergy, such as eczema or food allergy.<\/li>\n<li>There is a suspicion that eosinophilic immune cells are involved in your symptoms.<\/li>\n<li>Previous gastrointestinal testing has not provided a clear explanation and you want targeted additional information.<\/li>\n<\/ul>\n<\/div>\n<div class=\"dk-callout\">\n<p><strong>Important:<\/strong> EDN is an additional test. The test does not show which foods trigger a reaction and does not detect parasites. Other tests are required for this.<\/p>\n<\/div>\n[\/vc_column_text]\n[vc_column_text el_class=&#8221;dk-backtotop-wrap&#8221;]\n<a class=\"dk-backtotop\" href=\"#edn-productinformatie\"><span aria-hidden=\"true\">\u2191<\/span> Back to top<\/a><br \/>\n[\/vc_column_text]\n[\/vc_column][\/vc_row]\n[vc_row el_class=&#8221;dk-section dk-anchor-section&#8221; el_id=&#8221;wat-onderzoeken-we&#8221;][vc_column]\n[vc_column_text]\n<div class=\"dk-category-heading\">\n<div class=\"dk-category-heading__accent\" aria-hidden=\"true\"><\/div>\n<div>\n<h2>What do we test?<\/h2>\n<p>We measure the amount of eosinophil-derived neurotoxin (EDN) in your stool.<\/p>\n<\/div>\n<\/div>\n<div class=\"dk-card\">\n<ul>\n<li>We measure the amount of EDN in your stool. EDN is a protein released by eosinophils, a type of white blood cell.<\/li>\n<li>The result is compared with the laboratory&#8217;s reference values.<\/li>\n<\/ul>\n<p>The test provides information about eosinophilic immune activity in the gut, but not about its precise cause.<\/p>\n<\/div>\n[\/vc_column_text]\n[vc_column_text el_class=&#8221;dk-backtotop-wrap&#8221;]\n<a class=\"dk-backtotop\" href=\"#edn-productinformatie\"><span aria-hidden=\"true\">\u2191<\/span> Back to top<\/a><br \/>\n[\/vc_column_text]\n[\/vc_column][\/vc_row]\n[vc_row el_class=&#8221;dk-section dk-anchor-section&#8221; el_id=&#8221;wat-vertelt-de-uitslag&#8221;][vc_column]\n[vc_column_text]\n<div class=\"dk-category-heading\">\n<div class=\"dk-category-heading__accent\" aria-hidden=\"true\"><\/div>\n<div>\n<h2>What can the result tell you?<\/h2>\n<p>The result shows whether an increased amount of EDN was found in the sample tested.<\/p>\n<\/div>\n<\/div>\n<div class=\"dk-grid dk-grid--2\">\n<div class=\"dk-product-card\">\n<h3>Within the reference range<\/h3>\n<p>A value within the reference range means that no increased amount of EDN was found in the sample tested. This does not completely rule out an allergic or inflammatory reaction.<\/p>\n<\/div>\n<div class=\"dk-product-card\">\n<h3>Elevated value<\/h3>\n<p>An elevated value means that eosinophilic immune cells may be more active in the gastrointestinal tract. This can occur with various allergic or inflammatory reactions.<\/p>\n<\/div>\n<\/div>\n<div class=\"dk-callout\">\n<p><strong>The result alone does not establish a diagnosis.<\/strong> EDN cannot, for example, demonstrate a food allergy, worm infection or \u201cleaky gut\u201d. Targeted follow-up testing may be needed if the value is abnormal.<\/p>\n<\/div>\n[\/vc_column_text]\n[vc_column_text el_class=&#8221;dk-backtotop-wrap&#8221;]\n<a class=\"dk-backtotop\" href=\"#edn-productinformatie\"><span aria-hidden=\"true\">\u2191<\/span> Back to top<\/a><br \/>\n[\/vc_column_text]\n[\/vc_column][\/vc_row]\n[vc_row el_class=&#8221;dk-section dk-anchor-section&#8221; el_id=&#8221;uitleg-edn&#8221;][vc_column]\n[vc_column_text]\n<div class=\"dk-category-heading\">\n<div class=\"dk-category-heading__accent\" aria-hidden=\"true\"><\/div>\n<div>\n<h2>Explanation of the value tested<\/h2>\n<p>What eosinophil-derived neurotoxin can tell you about the activity of eosinophilic immune cells.<\/p>\n<\/div>\n<\/div>\n<div class=\"dk-card\">\n<h3>Eosinophil-derived neurotoxin (EDN)<\/h3>\n<p>Eosinophils are white blood cells of the immune system. They can become active in, among other things, certain allergic reactions, inflammation and parasitic worm infections. EDN is released in the process.<\/p>\n<p>Some of this can enter the stool. EDN can therefore provide information about the activity of these immune cells in the gut. The test does not indicate what causes this activity.<\/p>\n<\/div>\n[\/vc_column_text]\n[vc_column_text el_class=&#8221;dk-backtotop-wrap&#8221;]\n<a class=\"dk-backtotop\" href=\"#edn-productinformatie\"><span aria-hidden=\"true\">\u2191<\/span> Back to top<\/a><br \/>\n[\/vc_column_text]\n[\/vc_column][\/vc_row]\n[vc_row el_class=&#8221;dk-section dk-anchor-section&#8221; el_id=&#8221;hoe-werkt-de-test&#8221;][vc_column]\n[vc_column_text]\n<div class=\"dk-category-heading\">\n<div class=\"dk-category-heading__accent\" aria-hidden=\"true\"><\/div>\n<div>\n<h2>How does the test work?<\/h2>\n<p>From collecting the sample at home to the laboratory result with reference values.<\/p>\n<\/div>\n<\/div>\n<div class=\"dk-card\">\n<ol>\n<li>You order the EDN stool test and receive sampling materials with instructions.<\/li>\n<li>You collect a small amount of stool at home.<\/li>\n<li>You package and send the sample according to the instructions.<\/li>\n<li>The laboratory measures the amount of EDN.<\/li>\n<li>You receive the result with the corresponding reference values.<\/li>\n<\/ol>\n<\/div>\n[\/vc_column_text]\n[vc_column_text el_class=&#8221;dk-backtotop-wrap&#8221;]\n<a class=\"dk-backtotop\" href=\"#edn-productinformatie\"><span aria-hidden=\"true\">\u2191<\/span> Back to top<\/a><br \/>\n[\/vc_column_text]\n[\/vc_column][\/vc_row]\n[vc_row el_class=&#8221;dk-section dk-anchor-section&#8221; el_id=&#8221;uitslag-en-vervolgstappen&#8221;][vc_column]\n[vc_column_text]\n<div class=\"dk-category-heading\">\n<div class=\"dk-category-heading__accent\" aria-hidden=\"true\"><\/div>\n<div>\n<h2>Results and next steps<\/h2>\n<p>An elevated EDN value may be a reason for more targeted follow-up testing.<\/p>\n<\/div>\n<\/div>\n<div class=\"dk-card\">\n<p>Is the EDN value elevated? Additional testing may then be useful, depending on your symptoms and medical history. This might include allergy testing, calprotectin if intestinal inflammation is suspected, or parasite testing when indicated.<\/p>\n<p>Discuss an abnormal result with your doctor if necessary. Contact your GP if you have blood in your stool, unexplained weight loss, persistent fever or severe symptoms.<\/p>\n<\/div>\n[\/vc_column_text]\n[vc_column_text el_class=&#8221;dk-backtotop-wrap&#8221;]\n<a class=\"dk-backtotop\" href=\"#edn-productinformatie\"><span aria-hidden=\"true\">\u2191<\/span> Back to top<\/a><br \/>\n[\/vc_column_text]\n[\/vc_column][\/vc_row]\n[vc_row el_class=&#8221;dk-section dk-anchor-section&#8221; el_id=&#8221;veelgestelde-vragen&#8221;][vc_column]\n[vc_column_text]\n<div class=\"dk-category-heading\">\n<div class=\"dk-category-heading__accent\" aria-hidden=\"true\"><\/div>\n<div>\n<h2>Frequently asked questions<\/h2>\n<p>Answers to frequently asked questions about the EDN stool test.<\/p>\n<\/div>\n<\/div>\n[\/vc_column_text]\n[vc_tta_accordion style=&#8221;modern&#8221; shape=&#8221;rounded&#8221; color=&#8221;white&#8221; spacing=&#8221;4&#8243; gap=&#8221;3&#8243; c_icon=&#8221;chevron&#8221; c_position=&#8221;right&#8221; active_section=&#8221;-1&#8243; collapsible_all=&#8221;true&#8221;]\n[vc_tta_section title=&#8221;Can this test detect a food allergy?&#8221; tab_id=&#8221;edn-faq-01&#8243;]\n[vc_column_text]\nNo. EDN can be elevated in some allergic intestinal reactions, but it does not show whether you have a food allergy or which food is involved.<br \/>\n[\/vc_column_text]\n[\/vc_tta_section]\n[vc_tta_section title=&#8221;Can EDN indicate a worm infection?&#8221; tab_id=&#8221;edn-faq-02&#8243;]\n[vc_column_text]\nAn elevated EDN value can occur with some worm infections, but it does not detect worms. Targeted parasite testing is required for this.<br \/>\n[\/vc_column_text]\n[\/vc_tta_section]\n[vc_tta_section title=&#8221;Can I use this test to investigate a leaky gut?&#8221; tab_id=&#8221;edn-faq-03&#8243;]\n[vc_column_text]\nNo. EDN measures the activity of eosinophilic immune cells, not the permeability of the intestinal wall.<br \/>\n[\/vc_column_text]\n[\/vc_tta_section]\n[vc_tta_section title=&#8221;When is a standalone EDN test useful?&#8221; tab_id=&#8221;edn-faq-04&#8243;]\n[vc_column_text]\nIf you specifically want to know whether there are indications of eosinophilic immune activity. More extensive testing may be more appropriate for broader or unclear symptoms.<br \/>\n[\/vc_column_text]\n[\/vc_tta_section]\n[vc_tta_section title=&#8221;Does a normal EDN value rule out an allergic intestinal reaction?&#8221; tab_id=&#8221;edn-faq-05&#8243;]\n[vc_column_text]\nNo. Not every allergic or inflammatory reaction produces an elevated EDN value in stool.<br \/>\n[\/vc_column_text]\n[\/vc_tta_section]\n[vc_tta_section title=&#8221;Is any special preparation required?&#8221; tab_id=&#8221;edn-faq-06&#8243;]\n[vc_column_text]\nFollow the instructions provided. Do not change your diet or medication on your own initiative for this test.<br \/>\n[\/vc_column_text]\n[\/vc_tta_section]\n[\/vc_tta_accordion]\n[vc_column_text el_class=&#8221;dk-backtotop-wrap&#8221;]\n<a class=\"dk-backtotop\" href=\"#edn-productinformatie\"><span aria-hidden=\"true\">\u2191<\/span> Back to top<\/a><br \/>\n[\/vc_column_text]\n[\/vc_column][\/vc_row]\n[vc_row el_class=&#8221;dk-section dk-anchor-section&#8221; el_id=&#8221;contact-over-de-test&#8221;][vc_column]\n[vc_column_text]\n<div class=\"dk-category-heading\">\n<div class=\"dk-category-heading__accent\" aria-hidden=\"true\"><\/div>\n<div>\n<h2>Questions about this test?<\/h2>\n<p>Contact us if you are unsure whether the EDN stool test is suitable for your symptoms.<\/p>\n<\/div>\n<\/div>\n<div class=\"dk-callout\">\n<p>Unsure whether this test is suitable for your symptoms? Contact Darmklachten.nl. We will be happy to help you choose an appropriate test.<\/p>\n<\/div>\n[\/vc_column_text]\n[vc_btn title=&#8221;Contact us&#8221; style=&#8221;custom&#8221; custom_background=&#8221;#478BAE&#8221; custom_text=&#8221;#ffffff&#8221; shape=&#8221;round&#8221; el_class=&#8221;dk-readmore&#8221; link=&#8221;url:https%3A%2F%2Fwww.darmklachten.nl%2Fen%2Fcontact%2F|&#8221;]\n[vc_column_text el_class=&#8221;dk-backtotop-wrap&#8221;]\n<a class=\"dk-backtotop\" href=\"#edn-productinformatie\"><span aria-hidden=\"true\">\u2191<\/span> Back to top<\/a><br \/>\n[\/vc_column_text]\n[\/vc_column][\/vc_row]\n[vc_row el_class=&#8221;dk-section dk-anchor-section&#8221; el_id=&#8221;test-aanvragen&#8221;][vc_column]\n[vc_column_text]\n<div class=\"dk-category-heading\">\n<div class=\"dk-category-heading__accent\" aria-hidden=\"true\"><\/div>\n<div>\n<h2>Order an EDN stool test<\/h2>\n<p>Targeted testing of eosinophilic immune activity in the gut.<\/p>\n<\/div>\n<\/div>\n<div class=\"dk-callout\">\n<p><strong>Would you like to know whether there are indications of increased eosinophilic immune activity in your gut?<\/strong><\/p>\n<p>You can order the EDN stool test at the top of this page.<\/p>\n<\/div>\n[\/vc_column_text]\n[vc_column_text el_class=&#8221;dk-backtotop-wrap&#8221;]\n<a class=\"dk-backtotop\" href=\"#edn-productinformatie\"><span aria-hidden=\"true\">\u2191<\/span> To top<\/a><br \/>\n[\/vc_column_text]\n[\/vc_column][\/vc_row]\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Eosinophil-derived neurotoxin (EDN) is a protein that increases in response to (food) allergies and bacterial or viral inflammation. EDN also increases with worm infections, and high values may also be associated with a leaky gut.<\/p>\n<p>The <span style=\"color: #33cccc;\"><strong>EDN<\/strong> <\/span>module measures the concentration in stool of:<\/p>\n<ul>\n<li><a href=\"https:\/\/www.darmklachten.nl\/en\/testen\/eosinophil-derived-neurotoxin-edn\/\" target=\"_blank\" rel=\"noopener\">Eosinophil-derived neurotoxin<\/a><\/li>\n<\/ul>\n","protected":false},"featured_media":59316,"template":"","meta":{"_acf_changed":false},"product_brand":[],"product_cat":[164,163],"product_tag":[],"class_list":["post-59315","product","type-product","status-publish","has-post-thumbnail","product_cat-modules-3","product_cat-allergy-and-intolerance","pa_aandoening-celiac-disease-gluten-intolerance","pa_aandoening-crohns-disease","pa_aandoening-histamine-intolerance","pa_aandoening-lactose-intolerance","pa_aandoening-leaky-gut","pa_aandoening-ulcerative-colitis","pa_symptoom-constipation","pa_symptoom-heart-palpitations","pa_symptoom-insomnia-with-intestinal-complaints","entry","has-media","first","instock","taxable","shipping-taxable","purchasable","product-type-simple","col","wpex-woo-entry","span_1_of_3 span_1_of_2_tl span_1_of_2_tp span_1_of_1_pl span_1_of_1_pp"],"bundled_by":[],"bundle_stock_status":"instock","bundle_stock_quantity":null,"bundle_virtual":false,"bundle_layout":"","bundle_add_to_cart_form_location":"","bundle_editable_in_cart":false,"bundle_sold_individually_context":"","bundle_item_grouping":"","bundle_min_size":"","bundle_max_size":"","bundle_price":[],"bundled_items":[],"bundle_sell_ids":[],"acf":[],"wcpa_form_fields":null,"_links":{"self":[{"href":"https:\/\/www.darmklachten.nl\/en\/wp-json\/wp\/v2\/product\/59315","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.darmklachten.nl\/en\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/www.darmklachten.nl\/en\/wp-json\/wp\/v2\/types\/product"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.darmklachten.nl\/en\/wp-json\/wp\/v2\/media\/59316"}],"wp:attachment":[{"href":"https:\/\/www.darmklachten.nl\/en\/wp-json\/wp\/v2\/media?parent=59315"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/www.darmklachten.nl\/en\/wp-json\/wp\/v2\/product_brand?post=59315"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/www.darmklachten.nl\/en\/wp-json\/wp\/v2\/product_cat?post=59315"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/www.darmklachten.nl\/en\/wp-json\/wp\/v2\/product_tag?post=59315"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}