Gluten sensitivity
€ 108,00
Gluten consists of proteins found in grains such as wheat, rye and spelt, and an intolerance to gluten is called coeliac disease, although it is actually a lifelong inflammatory disease that develops in response to gluten. The stool is tested for antibodies against anti-gliadin and anti-ht-transglutaminase, and an increase in these antibodies indicates that the body reacts negatively to gluten. Please note: high values are not proof of gluten intolerance (coeliac disease), but they do indicate an increased risk of this disease.
The GLUTEN module examines the concentrations in the stool of:
- Secretory IgA
- Anti-ht-Transglutaminase
- Anti-Gliadin sIgA
€ 108,00
Description
Gluten sensitivity – testing for antibodies against gluten
Do you regularly have gastrointestinal symptoms and suspect that gluten may play a role? This stool test measures antibodies against gliadin (a component of gluten) and tissue transglutaminase. Total sIgA is also important for interpretation. This is an antibody found in the intestine.
Together, these results provide additional information about a possible immune response in the intestine, but they do not diagnose celiac disease, wheat allergy or gluten sensitivity.
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Gluten: not every reaction is the same
Celiac disease, wheat allergy and non-celiac gluten sensitivity are different conditions or symptom patterns.
The terms gluten sensitivity, allergy, hypersensitivity and reaction are often used interchangeably, but they do not mean the same thing.
- Celiac disease is an autoimmune disease.
- Wheat allergy is an allergic reaction to wheat proteins.
- Non-celiac gluten sensitivity means that symptoms develop after consuming gluten-containing foods without celiac disease or wheat allergy having been demonstrated.
The word “reaction” is a general term and by itself does not indicate the cause.
When is this test suitable?
Targeted additional testing for antibodies in stool when you have questions about gluten and gastrointestinal symptoms.
- You regularly experience abdominal pain, bloating or diarrhea and suspect a connection with gluten-containing foods.
- Your symptoms persist without a clear explanation and you want targeted additional testing.
- You have previously had abnormal test results and specifically want these antibodies measured in stool.
- You want additional information about antibodies to gluten alongside any testing already performed.
When is conventional celiac testing important?
Do you have persistent abdominal symptoms, unexplained anemia, unintentional weight loss, or a first-degree relative with celiac disease? Discuss with your doctor whether testing for celiac disease is needed. In children, poor growth and persistent abdominal symptoms may also be reasons for testing.
If celiac disease is suspected, blood testing through a doctor is the recommended first step, usually for anti-tTG-IgA and total IgA. This stool test is not a substitute for that.
What do we test?
Three stool measurements that are always interpreted together.
Anti-gliadin
Antibodies against gliadin, a protein component of gluten.
Anti-tTG
Antibodies against tissue transglutaminase, an enzyme naturally present in the body that plays an important role in celiac disease.
Total sIgA
The total amount of secretory IgA in stool. This value helps interpret the two specific antibody measurements.
Why measure total sIgA as well? If total sIgA is very low, anti-gliadin and anti-tTG may also be low. Values within the reference range then do not automatically mean that a gluten-related reaction has been ruled out.
What can the results tell you?
The antibody values and total sIgA must be interpreted together.
Within the reference range
A result within the reference range means that the measured anti-gliadin and anti-tTG are not elevated according to the method used. Always consider total sIgA as well.
Elevated antibody values
If anti-gliadin or anti-tTG is elevated, more of these antibodies were detected. This may be consistent with an immune response to gluten, but it does not automatically mean that you have celiac disease, wheat allergy or gluten sensitivity.
With very low total sIgA low anti-gliadin or anti-tTG values are more difficult to interpret. The test cannot diagnose or rule out celiac disease, nor can it determine on its own what is causing your symptoms.
Explanation of the values tested
What anti-gliadin, anti-tTG and total sIgA mean in this test.
Anti-gliadin
Gluten consists of proteins found in foods such as wheat, rye, barley and spelt. Gliadin is a component of gluten from wheat. The immune system can produce antibodies against gliadin.
The test examines whether these antibodies are present in stool and in what quantity. An elevated value on its own is not specific for celiac disease.
Anti-tTG)
Tissue transglutaminase is an enzyme that occurs naturally in the body. In celiac disease, the immune system can produce antibodies against this enzyme.
Anti-tTG in blood is an important part of conventional celiac diagnostics. Measurement in stool is less well studied and does not have the same diagnostic significance.
Total sIgA
Secretory IgA is an important antibody in the intestinal mucosa. The total value indicates how much sIgA is present in the sample.
This is important because anti-gliadin and anti-tTG are assessed as IgA antibodies in this test. If total sIgA is very low, these specific values may also be low.
How does the test work?
From collecting a sample at home to receiving the result with measured values and reference ranges.
- You order the Gluten sensitivity test and receive the required collection materials with instructions.
- You collect a small amount of stool at home according to the supplied instructions.
- You package and send the sample according to the instructions.
- The laboratory measures anti-gliadin, anti-tTG and total sIgA in the stool.
- You receive the laboratory report with the measured values and corresponding reference ranges.
Results and next steps
If celiac disease is a concern, conventional medical diagnostics remain important regardless of the stool result.
The report shows the results for anti-gliadin, anti-tTG and total sIgA. These values are assessed together.
If values are abnormal, or if total sIgA is low and therefore makes the antibody values more difficult to interpret, additional testing through your doctor may be appropriate. If celiac disease is suspected, this usually consists of blood testing for anti-tTG-IgA and total IgA.
Further testing may also be useful if anti-gliadin and anti-tTG are within the reference range, especially if you have clear symptoms, a relevant medical history or very low total sIgA.
Continue eating gluten until any celiac testing has been completed, unless your doctor advises otherwise. Starting a gluten-free diet beforehand can reduce the reliability of conventional diagnostics.
Frequently asked questions
Answers to questions about gluten, antibodies in stool and follow-up testing.
Celiac disease is an autoimmune disease. Wheat allergy is an allergic reaction to proteins in wheat and is investigated differently. With non-celiac gluten sensitivity, symptoms occur after consuming gluten-containing foods even though celiac disease and wheat allergy have not been demonstrated. There is no single stool test that can reliably distinguish these three causes from one another.
Total sIgA shows how much of this antibody is present in the intestine. If the amount is very low, anti-gliadin and anti-tTG may also be low. A result that appears normal at first glance may therefore be more difficult to interpret. Low antibody values then do not rule out a gluten-related reaction.
If you specifically want the two antibody values measured in stool, this individual test provides a targeted measurement. Conventional medical testing remains necessary to diagnose or rule out celiac disease.
Yes. In addition to gluten, wheat contains other components, including certain carbohydrates that can cause gastrointestinal symptoms in some people. Wheat allergy is also possible.
No. A normal stool result is not reliable enough for that. If there is an appropriate suspicion, conventional blood testing is needed, sometimes followed by additional investigations.
No. Do not start a gluten-free diet on your own while celiac disease still needs to be investigated. Follow the supplied collection instructions and consult your doctor if you are unsure.
Questions about this test?
Contact us if you are unsure whether this individual test fits the question you want investigated.
Not sure whether this individual test is appropriate for your question, or whether another test for gluten and gastrointestinal symptoms would be more suitable? Contact Darmklachten.nl. We will be happy to help you choose an appropriate test.
Order the Gluten sensitivity test
Targeted stool testing for anti-gliadin, anti-tTG and total sIgA.
Would you like to have antibodies against gliadin and tissue transglutaminase, together with total sIgA, measured in your stool?
You can order the Gluten sensitivity test at the top of this page.
Additional information
| Symptomen | Abdominal pain, Acidic stool, Anal itching, Bloating, Chronic diarrhea, Constipation, Depression, Fatigue, Flatulence, Foul-smelling stool, Green stool, Hair loss, Headache, Heartburn, Intestinal complaints bread, Intestinal obstruction, Itching, Nausea and vomiting, Overweight, Pale stool, Rumbling Bowels, Soft, mushy stools, Stomach pain, Weight Loss, Yellow stool |
|---|---|
| Package options | Gluten package, Gluten package + zonulin |
| Aandoeningen | Abnormal Gut Flora, Celiac disease – gluten intolerance, Irritable Bowel Syndrome / Spastic Colon, Leaky gut |
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